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By Robert L. Weber

This anthology offers an perception into the wit and mind of the medical brain via a mix of a laugh and severe contributions written by way of and approximately scientists. The contributions checklist altering attitudes inside of technological know-how and reflect the interactions of technology with society.

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1991). Minisatellite repeat coding as a digital approach to DNA typing. Nature, 354, 204-9. Jeffreys, A. , Monckton, D. , Neil, D. L. & Armour, J. A. L. (1994). Complex gene conversion events in germline mutation at human minisatellites. Nature Genetics, 6, 136-45. Jobling, M. A. (1994). A survey of long-range DNA polymorphisms on the human Y chromosome. Human Molecular Genetics, 3, 107-4. Jobling, M. , Dover, G. A. & Jeffreys, A. J. (1994). Digital coding of human Y chromosomes: MVR-PCR at Y-specific minisatellites.

Genomics, 11, 83-92. Devlin, B. & Risch, N. (1992). Ethnic differentiation at VNTR loci, with special reference to forensic applications. American Journal of Human Genetics, 51, 534-48. Devlin, B. & Risch, N. (1993). Physical properties of VNTR data and their impact on a test of allelic independence. American Journal of Human Genetics, 53, 324-9. , Risch, N. & Roeder, K. (1990). No excess of homozygosity at loci used for DNA fingerprinting. Science, 249, 1416-20. , Risch, N. & Roeder, K. (1991).

This probe contains a minisatellite (M13-ms) which consists of repeating 15 bp sequences GAGGGTGGXGGXTCT. It detects a set of hypervariable regions in human DNA and makes it possible to estimate individual specificity as well as to establish paternity relationships. Ryskov et al. (1988) tested M13-ms for hybridization with DNA from many species and demonstrated a wide distribution of this MS in different taxonomic groups including man, animals, plants, bacteria. This peculiar characteristic of M13-ms allows one to apply its analysis for studying genomic diversity in different species.

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