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Radiationwith matterandas a tooitoprobepkysica[ and chemicalstructure. k-reso[vedpbotoemissionpectra k the %@ok approximation,”whichpredia eiectrong“ecti”onpatterns asafin~”on ofangkt Nm workp~ormedat theALS ii be~ingto dq$ne the limitsofthisapproximation and refine our understandingofphotoemission. 6=0, quadrupole and magnetic-dipole effects, and predicts simple electron ejection patterns as a function of angle. In the dipole approximation, a single parameter, ~, completely describes electron angular distributions as a function of the angle, 0, relative to the c polarization, E, of the ionizing radiation (Figure 3).

For these genesis. Only certain MMPs act within the context of each disease. For example, some members of the collagenase subfirnily of MMPs are associated with osteoarthritis. Disease treatment therefore requires development of selective inhibitors of MMPs. The structures of the human collagenase with bound inhibitors provide the basis for understandhg the selectivity profile ofa novel series of MMP inhibitors that are being investigated as a part of the Roche Bioscience structure-based drug-design program for inflammatory diseases.

Radiationwith matterandas a tooitoprobepkysica[ and chemicalstructure. k-reso[vedpbotoemissionpectra k the %@ok approximation,”whichpredia eiectrong“ecti”onpatterns asafin~”on ofangkt Nm workp~ormedat theALS ii be~ingto dq$ne the limitsofthisapproximation and refine our understandingofphotoemission. 6=0, quadrupole and magnetic-dipole effects, and predicts simple electron ejection patterns as a function of angle. In the dipole approximation, a single parameter, ~, completely describes electron angular distributions as a function of the angle, 0, relative to the c polarization, E, of the ionizing radiation (Figure 3).

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