By Ronald Wetzel, Indu Kheterpal
The power of polypeptides to shape however folded, polymeric constructions equivalent to amyloids and similar aggregates is being more and more famous as an immense new frontier in protein learn. This new quantity of tools in Enzymology in addition to half B (volume 412) on Amyloid, Prions and different Protein Aggregates proceed within the culture of the 1st quantity (309) in containing distinct protocols and methodological insights, supplied through leaders within the box, into the most recent equipment for investigating the buildings, mechanisms of formation, and organic actions of this significant classification of protein assemblies.
* provides specified protocols
* comprises troubleshooting information
* offers assurance on structural biology, computational tools, and biology
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Extra info for Amyloid, Prions, and Other Protein Aggregates, Part C
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Amyloid 7, 166–178. , and Glabe, C. G. (1997). Soluble amyloid A‐(1‐40) exists as a stable dimer at low concentrations. J. Biol. Chem. 272, 21037–21044. , and Schulz, R. Z. (1940). Amyloid. 1. Methods of isolating amyloid from other tissue elements. Arch. Pathol. 30, 240–259. , and Sato, K. (2003). Spherical aggregates of ‐amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase‐3. Proc. Natl. Acad. Sci. USA 100, 6370–6375. Hou, L. , Shao, H. , Zhang, Y.